Hey guys, long time no post. Trust me, there’s more coming soon when I can find the time to talk about some of the recent metal-centric work coming from our lab.
In the meantime, I’ve entered the Centenary Institute’s Lawrence Creative Prize for 2016 on my current research obsession: early life iron overload and Parkinson’s disease. Here’s a video we shot:
You can vote over here, all you need to do is create an account, or log in via Facebook or your Google account. Be sure to check out the other submissions too, you can vote more than once.
Lead has been in the news a lot recently; you’d have to be hiding under a rock to not know about the current environmental tragedy happening in Flint, Michigan, where toxic levels of lead have been found in the municipal water supply.
Although lead as many practical uses, it’s probably just as famous as being extremely poisonous. Similarly, manganese, which unlike lead actually has an essential role in normal physiology, is also toxic when present at high levels. In an upcoming special issue on the neurotoxicity of lead, manganese and mercury in Ferrumblogger’s favourite journal Metallomics (you can access the article for free here), we’ve just published findings from the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing, one of the world’s largest group of Alzheimer’s disease patients, looking at whether lead and manganese in blood can be used to predict the disease.
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It’s been a while since we’ve been active here, but as annual money-begging season has drawn to a close, it’s time to update everyone on the slew of new papers coming from our lab. Over the next few weeks, there’ll be a bunch more posts on the exciting developments happening in the ferrumblogger world.
To start, we’re going to look at a new paper, written by Florey PhD student Stuart Portbury, who’s been looking at how the brain responds to traumatic brain injury, or TBI. TBI is a hot topic right now, from the dangers of multiple concussions experienced by American NFL players (and the controversy regarding the recent pull-out by the NFL for a multi-million dollar project to study it’s effects in living patients) to people who like to get into locked cages and punch each other in the head (hey, consenting adults and all that…). And perhaps the biggest elephant in the room are the effects of traumatic brain injuries in the multiple sites of conflict currently taking place around the world.
What causes the long-lasting effects of concussions are still a matter of much contention, so it’s important for us to know what’s going on at the chemical level in precisely controlled conditions to better understand both how the brain responds, and what can be done to prevent it. Click through to read about thr work from Stuart and his supervisor, Associate Professor Paul Adlard, who runs the Synaptic Neurobiology Laboratory at the Florey. (Picture used from the US National Library of Medicine).
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If you are reading this blog it seems likely that you’ll have at least a passing familiarity with some (perhaps even many) kinds of “-omics”. Increasingly for every conceivable “-ome” there is a corresponding “-omics” aimed at the “collective characterisation and quantification of pools of biological molecules that translate into the structure, function, and dynamics of an organism or organisms” (well said Wikipedia!). Indeed a quick google reveals a long list of “-omes” each the target of study for an associated group of dedicated “-omics” researchers. The ease with which one can find commentary espousing the power of “-omics” to revolutionise < insert field of study here > coupled with the rapid spread of these neologisms through the scientific literature might even tempt the more cynical among us to utter those most scientifically contemptuous terms “buzz word” or “fishing trip” when discussing the latest results from some or another “-omic” study.
Full disclosure: I have occupied precisely this position. However, I write now as a (surprised) convert. This change evolved stealthily and I recognised my new position only recently; I had occasion to be evangelising about the importance of bioinorganic chemistry to fundamental biology (as is my want) and realised I am completely comfortable with the terms “metallome” and “metallomics”. On reflection this struck me as hypocritical, how suspicious that the “-omics” I hold in high esteem – metallomics – happens to be the very one pertaining to my area of study? …
Obviously my personal relegation of “-omics” to the “buzz-word” bin stemmed from ignorance. By necessity every scientist carves out a small portion of nature to chip away at while we look for insight and the great number of “-omics” simply reflects the diversity of worthy biochemical mysteries that remain to be solved. While each “-omics” has its star, be they genes, proteins, mRNA or metals, I am hearted to realize that the spread of “-omics” reflects researchers seeking greater context for their investigations. While establishing that A+B ⇄ C remains the cornerstone of the fruitful reductionist approache to biochemistry the benefit of “-omics” is that this interaction can be seen in a more complete way. I think Hiroki Haraguchi from Nagoya University, in his 2004 JAAS article, does a great job of contextualising metallomics by making the point that genomics, proteomics, metabolomics, metallomics etc. must all develop together.
I for one am excited to be following my line of metal biology focused enquiry as part of our collective effort to understand how the physical processes occurring inside the bags of chemicals we call cells ultimately gives rise to such interesting biology.
Dr Fiona Larner from the University of Oxford’s Department of Earth Sciences might not sound like she’s in the right place to be studying cancer, but Fiona’s work is a testament to how understanding the role of metals in disease takes more than just your run-of-the-mill biologist (sorry, biologists)
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…I’ve finally got around to updating our publications for 2015. You can find them here, and a lot of them are open access, so you can take a look for free. More will be added over the coming days.
Caenorhabditis elegans might not be an animal you’re particularly familiar with, but this humble little worm is one of the most important tools we have for studying metals in biological systems. These 1 mm long roundworms are self-fertilising, meaning you can raise literally millions of genetically identical offspring, and they were the first multi-cellular organism to have their entire genome mapped.
In a paper we’ve just published (coming from blog contributor Dr Gawain McColl) in Metallomics (grab it for free here), we partnered with researchers at the Australian Synchrotron’s X-ray Fluorescence Microscopy beamline and our new collaborator Dr Verena Wimmer, who runs the great Florey Advanced Microscopy Facility to look at how we can use a range of different techniques to examine metals in this worm at sub-micrometre levels.
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We’ve been harping on about our recent Chemical Science paper, which officially was published this week and can be downloaded for free here. Firstly, thanks to our friend Jonas Marnell of Ethix Design in Melbourne for the amazing cover artwork shown here.
Anyway, we’re not done showing off. We’ve been looking into how we can best represent the data we’ve been generating in new and exciting forms more digestible for the non-neuroscientists.
Read more about what we’ve been up to after the jump.
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