2012

Lei, P., Ayton, S., Finkelstein, D., Spoerri, L., Ciccotosto, G., Wright, W., Wong, B., Adlard, P.,  Cherny, R., Lam, L., Roberts, B.R., Volitakis, I., Egan, G., McLean, C., Cappai, R., Duce, J., Bush, A.I. Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export. Nature Medicine (2012) 18: p. 291-295.

McColl, G., Roberts, B.R., Pukala, T., Kenche, V., Roberts, C., Link, C., Ryan, T., Masters, C.L., Barnham, K.J., Bush, A.I., Cherny, R. Improved model of Aß1-42 toxicity in C. elegans shows rapid protection by 8-hydroxyquinoline. Molecular Neurodegeneration (2012) 7(1): p. 57.

Ryan, T., Friedhuber, A., Lind, M., Howlett, G., Masters, C.L., Roberts, B.R. Small Amphipathic Molecules Modulate Secondary Structure and Amyloid Fibril-forming Kinetics of Alzheimer Disease Peptide Aß1-42. Journal of Biological Chemistry (2012), 287: p. 16947-16954.

Hung, L., Villemange,  V., Cheng, L., Sherratt, N., Ayton, S., White, A., Crouch, P., Lim, L., Leong, S., Wilkins, S., George, J., Roberts, B., Pham, C., Chiu, F., Shackleford, D., Powell, A., Masters, C.L., Bush, A.I., O’Keefe, G., Culvenor, J., Cappai, R., Cherny, R., Donnelly, P., Hill, A.,  Finkelstein, D., Barnham. K.J. The hypoxia imaging agent, Cu(ATSM), is neuroprotective and improves motor and cognitive functions in multiple animal models of Parkinson’s disease. Journal of Experimental Medicine (2012), 209: p. 837-854.

Roberts, B.R., Ryan, T., Bush, A.I., Masters, C.L., Duce, J. The role of metallobiology and amyloid-β peptides in Alzheimer’s disease. Journal of Neurochemistry (2012) 120 S1: p. 149-166.

G. McColl,  S. James, S. Mayo, D. Howard, C. Ryan, R. Kirkham, G. Moorhead, D. Paterson, M. de Jonge, A. Bush. Caenorhabditis elegans maintains highly compartmentalized cellular distribution of metals and steep concentration gradients of manganese. PLOS One (2012), 7: e. 32685 (free access)

D. Hare, M. Gerlach, P. Riederer. Considerations for measuring iron in post-mortem tissue of Parkinson’s disease patients. Journal of Neural Transmission (2012), 119: p. 1515-1521

J. Lear, D. Hare, F. Fryer, P. Adlard, D. Finkelstein, P. Doble. High-resolution elemental bioimaging of Ca, Mn, Fe, Co, Cu and Zn employing LA-ICP-MS and hydrogen reaction gas. Analytical Chemistry (2012), 84: p. 6707-6714

D. Hare, J. Lee, A. Beavis, A. van Gramberg, J. George, P. Adlard, D. Finkelstein, P. Doble. Three-dimensional atlas of iron, copper, and zinc in the mouse cerebrum and brainstem. Analytical Chemistry (2012), 84: p. 3990-3997

D. Hare, C. Austin, P. Doble. Quantification strategies for elemental imaging of biological samples using laser ablation-inductively coupled plasma-mass spectrometry. The Analyst (2012), 137: p. 1527-1537

J. Lear, D. Hare, P. Adlard, D. Finkelstein, P. Doble. Improving acquisition times for elemental bio-imaging using quadrupole-based LA-ICP-MS. Journal of Analytical Atomic Spectroscopy (2012), 27: p. 159-164

SA James, I Volitakis, PA Adlard, JA Duce, CL Masters, RA Cherny & AI Bush. Elevated labile Cu is associated with oxidative pathology in Alzheimer disease, Free Radical Biology and Medicine (2012), 52(2): pp 298-302.

KA Price, JL Hickey, Z Xiao, AG Wedd, SA James, JR Liddell, PJ Crouch, AR White & PS Donnelly. The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells, Chemical Science (2012), 3(9): pp 2748-2759

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